Research Associate or Scientist I / Scientist II, Molecular Biology & Cell Culture
We are seeking an enthusiast researcher to work in the development of novel therapeutics harnessing the immune system to eliminate cancer. You will help guide the scientific direction of research and identify novel therapeutics. You will advance the pipeline through antibody discovery and engineering in order to produce and identify superior development candidates.
- Construct and produce novel antibodies and antibody-based products for therapeutic research and applications
- Implement technologies for antibody discovery, optimization and engineering using antibody phage display and next generation sequencing of immune and synthetic repertoires
- Purify potential therapeutic targets (antigens) and therapeutic (antibodies) using affinity, ion exchange and size exclusion chromatography
- Characterize and optimize the biophysical, biochemical and manufacturing properties of therapeutic candidates using mass spectroscopy (MS), analytical SEC, dynamic and static light scattering (MALLS)
- Evaluate the binding properties of therapeutic candidates using surface plasmon resonance (SPR / Biacore), biolayer interferometry (Octet), ELISA, FACS and similar techniques
- Work independently and make contributions to advance therapeutic candidate through development
- Prepare reports, manuscripts and meeting presentations – maintain accurate laboratory records
- Keep informed on the scientific literature and be an internal antibody expert
- Promote a science-driven, goal-oriented culture with innovation, accountability and transparency.
- Ph.D. in biochemistry, molecular biology, biophysics, bioengineering or a related field with 2-4 years of experience or M.S. or B.S. with 6+ years of experience
- Familiarity with standard HPLC chromatograph systems and simple automation
- Expertise in molecular biology, cloning mutagenesis, familiarity with standard skills in biochemistry, structural biology and computation skills for managing large data sets
- Experience with SDS-PGE electrophoresis, western blot, UV protein quantitation as well as standard plate-based assay techniques
- Strong analytical, problem-solving and decision-making skills
- Record of accomplishment as evidenced by publications, patents or public presentations
- Experience with written and oral communication skills, organization, multitasking and working in a collaborative and cross-functional research environment.
Amphivena Therapeutics, Inc. is a cancer immunotherapy company based in South San Francisco, CA that is developing proprietary first-in-class, T-cell redirecting bispecific antibody-based proteins for the treatment of cancer. The company’s lead drug candidate is AMV564, a CD33/ CD3 targeting bispecific that is currently in clinical trials for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
Amphivena’s mission is to eradicate cancers with breakthrough therapies that harness the patient’s own immune system to destroy tumor cells and their precursors. Our aim is to restore the cellular balance needed for proper blood formation, function and circulation, restoring the flow of life to patients.