About Amphivena Therapeutics

Amphivena Therapeutics, Inc. is a privately held, clinical-stage, immuno-oncology company that is developing a novel platform of dual-action biologics that relieve immune suppression and drive T-cell activation and polarization to restore anti-cancer immunity in patients

Science

Our science and platform target the suppressed immune system of cancer patients to restore anti-cancer immunity

The fundamental challenge in immuno-oncology is that a majority of patients do not respond to immunotherapies. Cancer patients exhibit tumor-induced immune suppression mediated by immune cell types such as myeloid derived suppressor cells (MDSC). T cell activating therapies can also trigger autoregulatory immune modulation, via MDSC recruitment.

Our proprietary platform is designed to potently and selectively deplete MDSC and to drive the activation and repolarization of T cells to relieve immune suppression and restore anti-cancer immunity in patients.

Platform

The Amphivena ReSTORE platform provides dual-action biologics that relieve immune suppression and activate
T cell effector function in cancer patients

The platform can be engineered with additional solid tumor targeting modalities to add functionality such as directed tumor cell killing

Portfolio

Our lead candidate, AMV564, is currently in clinical studies in both solid tumor and hematologic cancers

We are advancing additional bivalent, multi-target candidates through preclinical development

Press Release
June 23, 2020

Amphivena Presents Translational Data for its Lead Clinical Candidate, AMV564 at the AACR 2020 Virtual Annual Meeting II

South San Francisco, CA – May 29, 2020 — AMV564, a novel first-in-class agent that depletes MDSC and polarizes T cells, is being investigated in Ph1 clinical trials in advanced solid tumors and hematological cancers and is well tolerated with single-agent activity across both solid and heme malignancies…

Press Release
May 29, 2020

Amphivena Presents Data from First-in-Human Study of AMV564 in Solid Tumor Patients at the ASCO Virtual Annual Meeting 2020

South San Francisco, CA – May 29, 2020 — Initial data from the Phase 1 dose escalation trial in 18 patients with advanced solid tumors shows AMV564 administered subcutaneously was well tolerated, with no dose-limiting toxicities…

Press Release
May 29, 2020

Amphivena Therapeutics to Present at the Jefferies Virtual Healthcare Conference

South San Francisco, CA – May 29, 2020 — Amphivena Therapeutics, a clinical-stage immuno-oncology company focused on developing immunotherapeutics that restore anti-cancer immunity to the patient, today announced that Curtis Ruegg, Ph.D., President and CEO, will present a company overview at the Jefferies Virtual Healthcare Conference on Thursday, June 4, 2020 at 4:00 PM ET….

June 4, 2020 at 4:00 PM ET
View Jefferies Conference Webcast

Presentations & Publications