AMV564

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[text tag=”p” css_xs=”width:100%;” css=”width:65%;display:inline-block;” typography=”Text {line-height: 36px;font-size: 18px;text-transform: none;text-align: justify;}”]AMV564 is a
homodimer that forms four single chain variable fragments (scFvs) which bind
CD33 on myeloid cells and CD3 epsilon on the T cell receptor.  Ternary
complexes produce an immune synapse that leads to T cell-directed lysis of target
cells.  [/text]
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[text tag=”p” css_xs=”width:100%;” css=”width:65%;display:inline-block;” typography=”Text {line-height: 36px;font-size: 18px;text-transform: none;text-align: justify;}”]CD33 is highly expressed on MDSC and leukemic blasts. Upon activation, CD33 relocalizes to glycolipid-enriched domains (lipid rafts). An important ligand for CD33 is the sialoglycan S100A9, which promotes expansion and production of immune-suppressive cytokines and factors by MDSC via CD33 engagement (1).[/text]

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[text tag=”h6″ css_xs=”width:100%;” css=”width:65%;display:inline-block;” typography=”Text {line-height: 21px;font-size: 14px;text-transform: none;text-align: justify;}”](1) Chen X, Eksioglu EA, Zhou J, et al. Induction of
myelodysplasia by myeloid-derived suppressor cells. J Clin Invest. 2013
Nov;123(11):4595-611.[/text]

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