Research Associate or Scientist I / II

Company

Amphivena Therapeutics, Inc. is an immuno-oncology company based in South San Francisco, CA that is developing best-in-class T-cell engagers. The company’s lead drug candidate, AMV564, is a bivalent, bispecific CD33/ CD3 T cell engager that is selective for leukemic blasts and myeloid derived suppressor cells (MDSC), sparing normal myeloid cells (e.g., neutrophils and monocytes). To date, over 60 patients have received AMV564 across three Phase 1 clinical trials for acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and solid tumors. Amphivena’s mission is to eradicate cancers with breakthrough therapies that harness the patient’s own immune system to destroy tumor cells and their precursors.

 

Summary

We are seeking a motivated researcher to work in the development of novel therapeutics harnessing the immune system to eliminate cancer. You will help guide the scientific direction of research and identify and evaluate novel therapeutics. You will advance both the pipeline and our understanding of our current clinical candidate through application of various immunology and molecular biology techniques and related analyses.

 

Responsibilities

  • Develop suitable assays to evaluate the impact of T cell engagers and related molecules on T cell activation and modulation of the T cell repertoire
  • Evaluate the impact of current and new pipeline molecules on myeloid suppressor cell biology and tumor targets
  • Support the production of antibody reagents and protein therapeutics using molecular biology and cell culture techniques
  • Develop and implement procedures for analysis of candidate therapeutics using various techniques including flow cytometry, ELISA, immunofluorescence
  • Analyze patient-derived samples using techniques such as ELISA and flow cytometry
  • Work independently and make contributions to advance selection of therapeutic candidates
  • Maintain accurate and up to date laboratory records
  • Prepare reports and contribute data to both internal and external meeting presentations
  • Proactively remain informed with respect to relevant scientific literature
  • Promote a science-driven, goal-oriented culture with innovation, accountability and transparency

 

Qualifications:

  • Ph.D. in molecular biology, biochemistry, cell biology or a related field with 2-4 years of experience or M.S. or B.S. with 6+ years of experience
  • Extensive hands-on experience in cell and molecular biology (required) and immunology
    (preferred) including in vitro and ex vivo culture of primary cells and cell lines, ELISA, flow cytometry, T cell and myeloid cell assays
  • Experience in development and implementation of assays to quantify cytokines, chemokines, and other relevant facts in human samples
  • Demonstrated track record of de novo assay development
  • Experience in working with antibodies and related analytical processes; experience with bispecific antibodies and/or T cell engagers preferred
  • Strong analytical, problem-solving and decision-making skills
  • Record of accomplishment as evidenced by inclusions on publications, patents or public presentations
  • Excellent written and oral communication skills, organization, multitasking and demonstrated ability to work in a collaborative research environment; experience in small companies or start-up settings is a bonus

 

TO APPLY:

Please send your CV to careers@amphivena.com