Scientist/Senior Scientist – Protein Chemistry & Engineering

Company

Amphivena Therapeutics, Inc. is an immuno-oncology company based in South San Francisco, CA that is developing best-in-class T-cell engagers as a key component of a novel biologic’s platform. The company’s lead drug candidate, AMV564, is a bivalent T cell engager that selectively depletes MDSC and leukemic blasts. AMV564 has demonstrated single-agent activity in both hematologic and solid tumor malignances. Amphivena’s mission is to eradicate cancers with breakthrough therapies that harness the patient’s own immune system to relieve immune suppression and destroy tumor cells.

 

Summary

We are seeking a motivated researcher to work in the development of novel therapeutics harnessing the immune system to eliminate cancer. You will play a pivotal role in the scientific direction of the research team, identifying, building and evaluating novel therapeutics and platforms. You will advance the pipeline through protein engineering and analyses of the physical properties of our platform molecules, to generate and identify superior clinical candidates for development.

 

Responsibilities

  • Design, construct and analyze novel T cell engagers to further advance the Amphivena ReSTORE™ platform
  • Identify potential new targets and alternative platform approaches to stimulate innate and/or adaptive immunity in a therapeutic context
  • Utilize and maintain relevant laboratory instrumentation for protein purification and analysis of protein production, stability and other physical properties necessary to advance clinical candidates
  • Work independently and make contributions to advance selection of therapeutic candidates
  • Analyze patient-derived samples using techniques such as ELISA and flow cytometry
  • Work independently and make contributions to advance selection of therapeutic candidates
  • Maintain accurate and up to date laboratory records
  • Prepare reports and contribute data to both internal and external meeting presentations
  • Proactively remain informed with respect to relevant scientific literature and conference findings
  • Proactively communicate key findings with the team and senior leadership
  • Promote a science-driven, goal-oriented culture with innovation, accountability and transparency

 

Qualifications:

  • Ph.D. in biochemistry, protein engineering or a related field with at least 4 years of relevant industry experience; applicants with alternative backgrounds including extensive hands-on experience are also invited to apply
  • Broad hands-on experience in the purification, stability analysis, formulation, and analysis of physical properties of therapeutic proteins is required
    • Significant hands-on experience with protein purification techniques such as affinity, ion exchange and size exclusion chromatography and familiarity with the operation and maintenance of associated instrumentation (e.g. AKTA)
    • Experience with assessment of protein stability and formulation using relevant techniques and instrumentation
    • Experience with analytical methods and instrumentation used for characterization of candidate therapeutic proteins including analytical size exclusion chromatography (HPLC), ELISA, biolayer interferometry (Octet), dynamic light scattering
  • Experience with protein engineering and related approaches to alter affinity, reduce immunogenicity, and other relevant considerations for pipeline molecules
    • Significant experience with antibody engineering and analysis, especially antibody domains (e.g. ScFv, VHH) or related constructs is strongly preferred
  • Fundamental skills in biochemistry, molecular biology and protein biology; experience with computational modeling and mutagenesis is a strong bonus
  • Strong analytical, problem-solving and decision-making skills
  • Record of accomplishment as evidenced by inclusion on publications, patents or public presentations
  • Excellent written and oral communication skills, organization, multitasking and demonstrated ability to work in a collaborative research environment; experience in small companies or start-up settings is a bonus

 

TO APPLY:

Please send your CV to careers@amphivena.com